GLP-1 peptides have become some of the most researched and discussed compounds in modern metabolic science. From Ozempic and Mounjaro to the newer Retatrutide, this class of compounds has attracted attention from medical professionals, researchers and the global public alike.
In this guide we explain what GLP-1 peptides are, how they work, the different types available and what the research says.
What are GLP-1 Peptides?
GLP-1 (Glucagon-Like Peptide-1) is a naturally occurring hormone produced in the gut in response to food intake. It plays a central role in regulating:
- Insulin secretion — stimulating the pancreas to release insulin when blood glucose is elevated
- Glucagon suppression — inhibiting glucagon release which reduces hepatic glucose production
- Gastric emptying — slowing the movement of food through the stomach
- Appetite regulation — acting on the brain to reduce hunger signals
GLP-1 receptor agonists are synthetic compounds that mimic or enhance these natural effects. They bind to GLP-1 receptors and activate the same pathways as the natural hormone but with a longer half-life — allowing once-weekly dosing.
Types of GLP-1 Peptides
Single GLP-1 Agonists
The original GLP-1 medications target only the GLP-1 receptor. Semaglutide — the active ingredient in Ozempic and Wegovy — is the most widely known single GLP-1 agonist.
Dual GLP-1/GIP Agonists
The second generation added GIP receptor activation. Tirzepatide — the active ingredient in Mounjaro and Zepbound — is a dual agonist that targets both GLP-1 and GIP receptors simultaneously, producing enhanced results over single agonists.
Triple Agonists
The newest generation, represented by Retatrutide, targets three receptors — GLP-1, GIP and glucagon. The addition of glucagon receptor activation increases energy expenditure and promotes fat oxidation, potentially producing superior results to both single and dual agonists.
GLP-1 Peptides Available at GLP1 Peptides
| Product | Type | Receptors | Status |
|---|---|---|---|
| Retatrutide | Triple agonist | GLP-1, GIP, Glucagon | Investigational |
| Tirzepatide (Mounjaro) | Dual agonist | GLP-1, GIP | FDA Approved |
| Semaglutide (Ozempic) | Single agonist | GLP-1 | FDA Approved |
| Semaglutide (Wegovy) | Single agonist | GLP-1 | FDA Approved |
| Tirzepatide (Zepbound) | Dual agonist | GLP-1, GIP | FDA Approved |
Research Peptides — BPC-157, GHK-Cu and NAD+
Beyond GLP-1 medications, GLP1 Peptides also stocks a range of research peptides including BPC-157 for cellular repair research, GHK-Cu for regenerative studies and NAD+ for metabolic and longevity research.
Shop All GLP-1 Peptides
Retatrutide, Mounjaro, Ozempic, Wegovy, Zepbound and more in stock
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